These have also been confirmed in both recent and past studies to have no adverse effects on the liver, blood, nervous system, or urinary tract. Hydroxyzine can also be used for the treatment of allergic conditions, such as chronic urticaria, atopic or contact dermatoses, and histamine-mediated pruritus. Insufficient data were available to compare the drug with benzodiazepines and buspirone. Ī systematic review concluded that hydroxyzine outperforms placebo in treating generalized anxiety disorder. Hydroxyzine is used in the treatment of itchiness, anxiety, and nausea due to motion sickness. In 2020, it was the 70th most commonly prescribed medication in the United States, with more than 10 million prescriptions. It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year. It is a first-generation antihistamine in the piperazine family of chemicals. Hydroxyzine works by blocking the effects of histamine. It is unclear if use during pregnancy or breastfeeding is safe. Serious side effects may include QT prolongation. Ĭommon side effects include sleepiness, headache, and a dry mouth. It is used either by mouth or injection into a muscle. It is used in the treatment of itchiness, insomnia, anxiety, and nausea, including that due to motion sickness. Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication.
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